|European Challenge Cup|
|Venue: Madejski Stadium Date: Saturday, 14 October Kick-off: 15:00 BST|
|Coverage: Updates on BBC local radio and live scores on the BBC Sport website|
Topsy Ojo will play his 279th London Irish game against Edinburgh, taking him one short of Justin Bishop’s club record of 280 appearances.
Hooker Tom Woolstencroft is given his Exiles debut after joining this week.
Richard Cockerill makes nine changes from the Edinburgh side that beat Zebre in the Pro14 last Saturday.
Glenn Bryce starts at full-back in place of the injured Blair Kinghorn, while Damian Hoyland comes in for Tom Brown on the wing.
London Irish and Edinburgh are in Pool Four alongside 2016 winners Stade Francais and Russian club Krasny Yar, who are making their first appearance in the competition.
London Irish: Ransom; Cokanasiga, Fowlie, Williams, Ojo (capt); Brophy Clews, Meehan; Elrington, Woolstencroft, Hoskins, Lloyd, McNally, Northcote-Green, Gilsenan, Lomidze.
Replacements: Gleave, Smallbone, Chawatama, Cooke, Curtis-Harris, Steele, Atkins, Loader.
Edinburgh: Bryce; Fife, Dean, Rasolea, Hoyland; Tolvey, Hidalgo-Clyne; Dell, McInally, Berghan, McKenzie (capt), Toolis, Ritchie, Hardie, Du Preez.
Replacements: Cochrane, Marfo, Nel, Gilchrist, Crosbie, Fowles, Brown, Harries.
Referee: Dan Jones (WRU)